Peroxisome Proliferator-Activated Receptor γ Coactivator 1 Coactivators, Energy Homeostasis, and Metabolism
نویسندگان
چکیده
منابع مشابه
Toll-like receptor-mediated inflammatory signaling reprograms cardiac energy metabolism by repressing peroxisome proliferator-activated receptor γ coactivator-1 signaling.
BACKGROUND Currently, there are no specific therapies available to treat cardiac dysfunction caused by sepsis and other chronic inflammatory conditions. Activation of toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) is an early event in Gram-negative bacterial sepsis, triggering a robust inflammatory response and changes in metabolism. Peroxisome proliferator-activated receptor-γ coactiv...
متن کاملPeroxisome proliferator-activated receptor-γ coactivator-1α in muscle links metabolism to inflammation
1. In higher eukaryotes, metabolism and immunity are tightly coupled. However, whereas evolutionary, a compromised immune response due to undernourishment has been the predominant problem, the inflammatory response to obesity and other life style-associated diseases gained in relevance in Western societies in the last hundred years. 2. Traditionally, fat tissue has been considered as the major ...
متن کاملThe effect of Nordic training on plasma levels of Peroxisome proliferator-activated receptor-γ coactivator 1-α and Sirtuin 6 in elderly women with diabetes
Introduction: Nordic walking training has many benefits in improving the condition of the disabled elderly. Then the aim of this study was to evaluate the effect of Nordic walking training on plasma levels of PGC1α and SIRT6 in elderly women with diabetes. Materials and Methods: In this quasi-experimental study, 27 elderly women (age: 65.45±2.70 years) with type 2 diabetes were selected and ran...
متن کاملPeroxisome Proliferator-Activated Receptor- Coactivator 1 (PGC-1 ): Transcriptional Coactivator and Metabolic Regulator
Investigations of biological programs that are controlled by gene transcription have mainly studied the regulation of transcription factors. However, there are examples in which the primary focus of biological regulation is at the level of a transcriptional coactivator. We have reviewed here the molecular mechanisms and biological programs controlled by the transcriptional coactivator peroxisom...
متن کاملthe role of peroxisome proliferator-activated receptor-coactivator-1 gene in skin aging
skin aging is a continuous process that exhibits fine and deep wrinkles, thin and transparent skin, loss of underlying fat, dry skin and itch, following decreased collagen and elastin synthesis. both extrinsic and intrinsic agents are considered in the pathogenesis on skin aging. extrinsic factors such as sun exposure, windy and dry weather, nutrition, and lifestyle may induce premature aging,...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Endocrine Reviews
سال: 2006
ISSN: 0163-769X,1945-7189
DOI: 10.1210/er.2006-0037